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- Bioss
- bs-2496P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2496P |
| 英文名称 | SPN Antibody Blocking Peptide |
| 中文名称 | CD43封闭多肽 |
| 英文别名 | CD 43; CD43 antigen; Galactoglycoprotein; Galactoglycoprotein; GALGP; GPL 115; GPL115; Human gene for sialophorin; Leucocyte sialoglycoprotein; Leucocyte sialoglycoprotein; LEUK_HUMAN; Leukocyte sialoglycoprotein; Leukosialin; LSN; Sialophorin (leukosialin); Sialophorin; SPN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Cell Type Markers > CD > Non-lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > NK Cell Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Neutrophil Lineage Stem Cells > Hematopoietic Progenitors > Myeloid > Thrombocytic Lineage |
| 亚基 | Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas. |
| 翻译后修饰 | Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures. |
| 功能 | One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017] |
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SPN Antibody Blocking Peptide(bs-2496P)-500ug
￥880
