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| 规格： | 100ug | 产品价格： | ￥1880.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 规格： | 20ug | 产品价格： | ￥580.0 |
| 产品编号 | bs-49153P |
| 英文名称 | Recombinant mouse CD84 protein, Trx & His |
| 中文名称 | 重组小鼠CD84蛋白 |
| 英文别名 | SLAM family member 5; Cell surface antigen MAX.3; eukocyte differentiation antigen; Hly9 beta; Leukocyte Antigen; Leukocyte differentiation antigen CD84; LY9B; Signaling lymphocytic activation molecule 5; SLAM family member 5; SLAMF5; SLAF5_MOUSE; Recombinant mouse CD84 protein, Trx & His |
| 性状 | Liquid |
| 纯化方法 | AC |
| 理论分子量 | 22.5 |
| 实际分子量 | 38 kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | 20mM Tris-HCl. |
| 研究领域 | Immunology > Adaptive Immunity > B Cells > CD Stem Cells > Hematopoietic Progenitors > Surface Molecules |
| 亚基 | Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 组织特异性 | Predominantly expressed in hematopoietic tissues such as lymph node, spleen, thymus, and bone marrow. Detected also in lung. |
| 翻译后修饰 | Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain |
| 相似性 | Contains 1 Ig-like C2-type (immunoglobulin-like) |
| 功能 | Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
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文献和实验Preparation of Recombinant Protein Spotted Arrays for Proteome‐Wide Identification of Kinase Targets
., Miller, P., Dean, R.A., Gerstein, M., and Snyder, M. 2001. Global analysis of protein activities using proteome chips. Science 293:2101‐2105. Zhu, X., Gerstein, M., and Snyder
Mouse Strains and Genetic Nomenclature
. Biol. J. Linnean Soc. 30:51‐58. Bulfield, G., Siller, W.G., Wight, P.A., and Moore, K.J. 1984. X chromosome‐linked muscular dystrophy (mdx) in the mouse. Proc. Natl. Acad
Protein‐Protein Interactions Identified by Pull‐Down Experiments and Mass Spectrometry
of these samples, and this is particularly true for the peripheral membrane extract (see note above). All frozen aliquots must be centrifuged after defrosting at 35,000 × g (or maximum speed) for 30 min at 4°C, before incubation with recombinant GST fusion protein
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