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| 规格： | 20ug | 产品价格： | ￥580.0 |
|---|---|---|---|
| 规格： | 100ug | 产品价格： | ￥1880.0 |
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 产品编号 | bs-49153P |
| 英文名称 | Recombinant mouse CD84 protein, Trx & His |
| 中文名称 | 重组小鼠CD84蛋白 |
| 英文别名 | SLAM family member 5; Cell surface antigen MAX.3; eukocyte differentiation antigen; Hly9 beta; Leukocyte Antigen; Leukocyte differentiation antigen CD84; LY9B; Signaling lymphocytic activation molecule 5; SLAM family member 5; SLAMF5; SLAF5_MOUSE; Recombinant mouse CD84 protein, Trx & His |
| 性状 | Liquid |
| 纯化方法 | AC |
| 理论分子量 | 22.5 |
| 实际分子量 | 38 kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | 20mM Tris-HCl. |
| 研究领域 | Immunology > Adaptive Immunity > B Cells > CD Stem Cells > Hematopoietic Progenitors > Surface Molecules |
| 亚基 | Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 组织特异性 | Predominantly expressed in hematopoietic tissues such as lymph node, spleen, thymus, and bone marrow. Detected also in lung. |
| 翻译后修饰 | Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain |
| 相似性 | Contains 1 Ig-like C2-type (immunoglobulin-like) |
| 功能 | Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
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文献和实验Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
biomarkers. Curr. Protoc. Protein Sci. 64:27.2.1?27.2.26. © 2011 by John Wiley & Sons, Inc. Keywords: protein microarray; antibodies; serum profiling
/ Mutations at the phenylalanine hydroxylase locus 192. PHEXdb http://data.mch.mcgill.ca/phexdb Mutations in PHEX gene causing X-linked hypophosphatemia 193. PMD http://pmd.ddbj.nig.ac.jp/ Compilation of protein mutant data 194. PTCH1 Mutation
Models and Analysis of Atherosclerosis, Restenosis, and Aneurysm Formation in the Mouse
. Deng, G.G., Martin‐McNulty, B., Sukovich, D.A., Freay, A., Halks‐Miller, M., Thinnes, T., Loskutoff, D.J., Carmeliet, P., Dole, W.P., and Wang, Y.X. 2003. Urokinase‐type plasminogen activator plays a critical
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