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- bs-4007P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-4007P |
| 英文名称 | ATG16A Antibody Blocking Peptide |
| 中文名称 | 自噬相关蛋白16A封闭多肽 |
| 英文别名 | A16L1_HUMAN; APG16 like 1; APG16-like 1; APG16L; APG16L beta; ATG16A; ATG16 autophagy related 16 like 1; ATG16 autophagy related 16-like 1 (S. cerevisiae); ATG16 autophagy related 16-like 1; ATG16A; ATG16L; ATG16L1; Autophagy related protein 16 1; Autophagy-related protein 16-1; FLJ00045; FLJ10035; FLJ10828; FLJ22677; IBD10; OTTHUMP00000164391; OTTHUMP00000164393; OTTHUMP00000165876; OTTHUMP00000165877; WD repeat domain 30; WDR30. |
| 纯化方法 | HPLC |
| 研究领域 |
Cancer > Cell Death > Autophagy > APG gene products Cancer > Cell Death > Autophagy > Signal Transduction Cancer > Oncoproteins/suppressors > Tumor suppressors Cancer > Signal transduction > Autophagy Cardiovascular > Heart > Autophagy > APG gene products Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ub-like Proteins Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > APG gene products Neuroscience > Neurology process > Neurodegenerative disease |
| 亚基 | Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). |
| 亚细胞定位 |
Cytoplasm |
| 组织特异性 |
Expressed in right hemisphere of cerebellum and 147 other tissues |
| 相似性 | Belongs to the WD repeat ATG16 family. Contains 7 WD repeats. |
| 功能 |
Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:29317426, PubMed:30778222, PubMed:33909989, PubMed:24553140, PubMed:24954904, PubMed:27273576). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010] |
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