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- Bioss
- bs-15459P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-15459P |
| 英文名称 | HERC1 Antibody Blocking Peptide |
| 中文名称 | 鸟苷酸释放因子p532蛋白封闭多肽 |
| 英文别名 | Guanine nucleotide exchange factor p532; Hect (homologous to the E6 AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1) like domain (RLD) 1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; HECT domain and RCC1 like domain containing protein 1; p532; p619; Probable E3 ubiquitin-protein ligase HERC1; HERC1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > Hect E3 Ligase Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Regulators |
| 亚基 | Interacts with TSC2; interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A. |
| 亚细胞定位 | Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin-rich surface protrusions. |
| 组织特异性 | Widely expressed. |
| 相似性 | Contains 1 B30.2/SPRY domain. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 14 RCC1 repeats. Contains 11 WD repeats. |
| 功能 | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HERC1 is a stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. |
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HERC1 Antibody Blocking Peptide(bs-15459P)-500ug
￥880
