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- Bioss
- bs-11272P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11272P |
| 英文名称 | WFS1 Antibody Blocking Peptide |
| 中文名称 | Wolfram综合征蛋白1封闭多肽 |
| 英文别名 | DFNA14; DFNA38; DFNA6; DIDMOAD; WFRS; WFS; Wolfram syndrome 1 (wolframin); Wolfram syndrome; WOLFRAMIN; WFS1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Growth factors > Insulin and insulin-like Metabolism > Types of disease > Metabolic disorders Neuroscience > Neurology process > Metabolism Neuroscience > Neurology process > Neurogenesis Neuroscience > Sensory System > Auditory system Neuroscience > Sensory System > Visual system Signal Transduction > Growth Factors/Hormones > Insulin / Insulin-like |
| 亚细胞定位 | Endoplasmic reticulum; endoplasmic reticulum membrane; multipass membrane protein |
| 组织特异性 | Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line. |
| 功能 | WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) (1) and its expression is induced in response to ER stress, partially through transcriptional activation (2,3). Research studies have shown that mutations in the WFS1 gene lead to Wolfram syndrome, an autosomal recessive neurodegenerative disorder defined by young-onset, non-immune, insulin-dependent diabetes mellitus and progressive optic atrophy (4). |
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WFS1 Antibody Blocking Peptide(bs-11272P)-500ug
￥880
