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- bs-7852P
- 2025年10月16日
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500ug
| 产品编号 | bs-7852P |
| 英文名称 | ZWINT Antibody Blocking Peptide |
| 中文名称 | 着丝粒ZW10相互作用蛋白1封闭多肽 |
| 英文别名 | HZwint1; KNTC 2 AP; KNTC2AP; MGC 117174; MGC117174; ZW10 interacting protein 1; ZW10 interactor; ZWINT 1; ZWINT1; ZWINT-1; ZWINT_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Spindle Epigenetics and Nuclear Signaling > Cell cycle > Chromosome Structure > Centromere Epigenetics and Nuclear Signaling > Chromosome Structure > Centromeres |
| 亚基 | Interacts with ZW10 and MIS12. Interacts with the NDC80subunit of the NDC80 complex specifically during mitosis. Alsointeracts with CASC5, CETN3, DSN1 and PMF1. |
| 亚细胞定位 | Nucleus. Chromosome, centromere,kinetochore. Note=Localizes to kinetochores from late prophase toanaphase. |
| 功能 | Part of the MIS12 complex, which is required forkinetochore formation and spindle checkpoint activity. Required totarget ZW10 to the kinetochore at prometaphase. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ZWINT is a component of the MIS12 complex, which is required for kinetochore function and spindle checkpoint activity. ZWINT interacts with ZW10 and targets it to the kinetochore at prometaphase. ZWINT is detectable on the kinetochore till late anaphase. Inhibition of ZWINT expression results in chromosome missegregation, spindle checkpoint failure and, ultimately, cell death upon cytokinesis. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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