- ￥880
- Bioss
- bs-10186P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-10186P |
| 英文名称 | NET1 Antibody Blocking Peptide |
| 中文名称 | 神经上皮细胞转化基因1封闭多肽 |
| 英文别名 | Neuroepithelial cell-transforming gene 1 protein; Proto-oncogene p65 Net1; Rho guanine nucleotide exchange factor 8; ARHGEF8; ARHG8_HUMAN; |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > G protein signaling > Small G proteins > Ras family Epigenetics and Nuclear Signaling > Transcription > Other factors Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Ras Family |
| 亚基 | Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1. |
| 亚细胞定位 | Cytoplasm (By similarity). Nucleus |
| 组织特异性 | Widely expressed. |
| 相似性 | Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. |
| 功能 | Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. |
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NET1 Antibody Blocking Peptide(bs-10186P)-500ug
￥880
