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- Bioss
- bs-7693P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7693P |
| 英文名称 | RNLS Antibody Blocking Peptide |
| 中文名称 | 肾胺酶封闭多肽 |
| 英文别名 | C10orf59; Chromosome 10 open reading frame 59; FLJ11218; Hypothetical protein LOC55328; MAO C; Monoamine oxidase C; RENALASE; Renalase, FAD dependent amine oxidase; RNLS antibody; RNLS_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Blood > Blood Pressure regulation Cardiovascular > Heart > Contractility > Inotropics Neuroscience > Neurotransmitter > Biogenic Amines > Adrenaline Neuroscience > Neurotransmitter > Biogenic Amines > Dopamine Neuroscience > Neurotransmitter > Biogenic Amines > Noradrenaline |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. |
| 相似性 | Belongs to the renalase family. |
| 功能 | Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Renalase, a novel FAD dependent amine oxidase, is secreted by the kidney, degrades circulating catecholamines, and modulates cardiac function and lowers systemic blood pressure. In vivo, it has been found to decrease cardiac contractility and heart rate and prevents a compensatory increase in peripheral vascular tone, possibly explaining the association between increased plasma catecholamines and heightened cardiovascular risk. The plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. The administration of renalase (or renalase mimics) may offer a new approach to the treatment of hypertension commonly found in renal disease, which is associated with a marked increase in cardiovascular disease. |
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RNLS Antibody Blocking Peptide(bs-7693P)-500ug
￥880
