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- Bioss
- bs-7602P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-7602P |
| 英文名称 | TIAF1 Antibody Blocking Peptide |
| 中文名称 | TGFB1诱导抗凋亡因子1封闭多肽 |
| 英文别名 | MAJN; TGFB1 induced anti apoptotic factor 1 (12 kDa TGF beta1 induced antiapoptotic factor); 12 kDa TGF-beta-1-induced antiapoptotic factor; TGFB1 induced anti apoptotic factor 1; TGFB1-induced anti-apoptotic factor 1; TIAF1_HUMAN; MAJN; SPR210; MYO18A; MYSPDZ; TGFB1 induced anti apoptotic factor 1. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Nuclear |
| 组织特异性 | Not detectable in normal kidney and liver. Up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells. |
| 功能 | This protein inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIP. It is involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TIAF-1 (TGF Beta 1-induced antiapoptotic factor 1), also known as MYO18A, MAJN or MYSPDZ, is a TGF Beta 1-induced anti-apoptotic factor that localizes to the nucleus and functions to inhibit the cytotoxic effects of TNF? TRADD and FADD. Two isoforms of mouse TIAF-1 exist and are designated MysPDZ-Alpha and MysPDZ-Beta. MysPDZ-Alpha consists of a KE-rich region, an N-terminal PDZ domain and a prevalent myosin homologous head region, while the MysPDZ-Beta isoform lacks the KE-rich region and PDZ domain. MysPDZ-Alpha is present in most tissues and is known to co-localize with the ER-Golgi complex and with membrane ruffles and filopodia. MysPDZ-Beta is expressed specifically in hematopoietic tissues and cell lines and shows dispersed localization in the cytoplasm. |
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TIAF1 Antibody Blocking Peptide(bs-7602P)-500ug
￥880
