- ￥880
- Bioss
- bs-15532P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-15532P |
| 英文名称 | IBTK Antibody Blocking Peptide |
| 中文名称 | Bruton酪氨酸激酶抑制剂蛋白封闭多肽 |
| 英文别名 | BTKI; IBtk; IBTK_HUMAN; inhibitor of Bruton agammaglobulinemia tyrosine kinase; Inhibitor of Bruton tyrosine kinase. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK. |
| 亚细胞定位 | Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation. Isoform 2: Nucleus. |
| 组织特异性 | Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. |
| 相似性 | Contains 3 ANK repeats. Contains 2 BTB (POZ) domains. Contains 3 RCC1 repeats. |
| 功能 | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | IBTK is a encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. |
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IBTK Antibody Blocking Peptide(bs-15532P)-500ug
￥880
