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- bs-8810P
- 2025年10月16日
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500ug
| 产品编号 | bs-8810P |
| 英文名称 | NUDT21 Antibody Blocking Peptide |
| 中文名称 | 剪切和多聚腺苷酸化特异性因子5封闭多肽 |
| 英文别名 | CFIM 25; CFIM25; Cleavage and polyadenylation specific factor 5 25 kD subunit; Cleavage and polyadenylation specific factor 5 25 kDa; Cleavage and polyadenylation specific factor 5; Cleavage and polyadenylation specificity factor 25 kDa subunit; Cleavage and polyadenylation specificity factor subunit 5; Cleavage factor Im complex 25 kDa subunit; CPSF 25; CPSF 25 kDa subunit; CPSF 5; CPSF25; CPSF5; CPSF5_HUMAN; DKFZp686H1588; Nucleoside diphosphate linked moiety X motif 21; Nucleoside diphosphate-linked moiety X motif 21; Nudix (nucleoside diphosphate linked moiety X) type motif 21; Nudix motif 21; NUDT 21; Nudt21; Pre mRNA cleavage factor Im (25kD); Pre mRNA cleavage factor Im 25 kDa subunit; Pre mRNA cleavage factor Im 25kD subunit; Pre-mRNA cleavage factor Im 25 kDa subunit. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing |
| 亚细胞定位 | Nucleus. In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles. |
| 翻译后修饰 | Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2. |
| 相似性 | Belongs to the Nudix hydrolase family. CPSF5 subfamily. Contains 1 nudix hydrolase domain. |
| 功能 | Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008] |
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NUDT21 Antibody Blocking Peptide(bs-8810P)-500ug
￥880
