- ￥880
- Bioss
- bs-13344P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-13344P |
| 英文名称 | GGA2 Antibody Blocking Peptide |
| 中文名称 | γ-衔接蛋白相关蛋白2封闭多肽 |
| 英文别名 | 1200007E24Rik; ADP ribosylation factor binding protein 2; ADP ribosylation factor binding protein GGA 2; ADP ribosylation factor binding protein GGA2; ADP-ribosylation factor-binding protein GGA2; ARF-binding protein 2; FLJ20966; Gamma adaptin related protein 2; gamma ear-containing; Gamma-adaptin-related protein 2; GGA 2; Gga2; GGA2_HUMAN; Golgi associated gamma adaptin ear containing ARF binding protein 2; Golgi localized gamma ear containing ARF binding protein 2; Golgi-localized; KIAA1080; Vear; VHS domain and ear domain containing protein; VHS domain and ear domain of gamma adaptin; VHS domain and ear domain of gamma-adaptin. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Trafficking > Organelle Proteins |
| 亚基 | Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity). Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2. |
| 亚细胞定位 | Golgi apparatus; trans-Golgi network membrane. Endosome membrane. |
| 组织特异性 | Ubiquitously expressed. |
| 翻译后修饰 | Ubiquitinated. |
| 相似性 | Belongs to the GGA protein family. Contains 1 GAE domain. Contains 1 GAT domain. Contains 1 VHS domain. |
| 功能 | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | A family of proteins, the GGAs (Golgi-localized, g-adaptin ear-containing, ARF-binding proteins) sequences that showed significant homology to the carboxy-terminal 'ear' domain of g-adaptin. Members of the GGA family (GGA1,GGA2 (also known as VEAR or VHS domain and ear domain of g-adaptin) and GGA3) are ubiquitous coat proteins that facilitate the trafficking of proteins between the trans-Golgi network and the lysosome. However, unlike g-adaptin, the GGAs are not associated with clathrin-coated vesicles or with any of the components of the AP-1 complex. GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membranes. GGA2 shares 45% amino acid sequence identity with GGA1 and 35% with GGA3. In addition to being involved in heterotypic vesicle/suborganelle interactions associated with the Golgi complex, GGA2 may have a tissue-specific function and is highly expressed in kidney, muscle and heart. Furthermore, the VHS domain of GGA2 binds to the acidic cluster-di-leucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR) and this is important for lysosomal enzyme targeting. |
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GGA2 Antibody Blocking Peptide(bs-13344P)-500ug
￥880
