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- Bioss
- bs-10925P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-10925P |
| 英文名称 | PRG2 Antibody Blocking Peptide |
| 中文名称 | 嗜酸性粒细胞颗粒关键碱性蛋白封闭多肽 |
| 英文别名 | BMPG; EMBP; Eosinophil granule major basic protein; Major Basic Protein; Eosinophil major basic protein; MBP; MBP1; Natural killer cell activator; Pregnancy-associated major basic protein; PRG 2; PRG2; PRG2_HUMAN; Proteoglycan 2; Proteoglycan 2 bone marrow; Proteoglycan 2 preproprotein. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Adaptive Immunity > T Cells > Cytotoxic Cells Immunology > Cell Type Markers > CD > NK Cells Tags & Cell Markers > Cell Type Markers > Other Cell Types |
| 亚基 | In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg. |
| 亚细胞定位 | Bone marrow proteoglycan: Secreted. Note=The proform is secreted.
Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core). |
| 组织特异性 | High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. |
| 翻译后修饰 | Nitrated. |
| 相似性 | Contains 1 C-type lectin domain. |
| 功能 | Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. |
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PRG2 Antibody Blocking Peptide(bs-10925P)-500ug
￥880
