- ￥880
- Bioss
- bs-7520P
- 2025年10月16日
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500ug
| 产品编号 | bs-7520P |
| 英文名称 | SPON1 Antibody Blocking Peptide |
| 中文名称 | 细胞外基质底物反应蛋白1封闭多肽 |
| 英文别名 | F spondin; F spondin extracellular matrix protein; FSPO; KIAA0762; MGC10724; SPON 1; spondin 1 (f spondin) extracellular matrix protein; Spondin 1; Spondin 1 extracellular matrix protein; Spondin 1 precursor; Spondin1; Vascular smooth muscle cell growth promoting factor; VSGP; VSGP/F spondin; SPON1_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP. |
| 亚细胞定位 | Secreted, extracellular space, extracellular matrix. |
| 组织特异性 | Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen. |
| 相似性 | Contains 1 reelin domain. Contains 1 spondin domain. Contains 6 TSP type-1 domains. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, and has also been implicated in inflammatory processes in the nervous system. |
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SPON1 Antibody Blocking Peptide(bs-7520P)-500ug
￥880
