- ￥880
- Bioss
- bs-18536P
- 2025年10月16日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-18536P |
| 英文名称 | PIP4K2A Antibody Blocking Peptide |
| 中文名称 | 磷脂酰肌醇-5-磷酸盐-4激酶2型α封闭多肽 |
| 英文别名 | phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; 1 phosphatidylinositol 4 phosphate 5 kinase 2 alpha; 1 phosphatidylinositol 4 phosphate 5 kinase; 1 phosphatidylinositol 4 phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; 4 5 kinase B isoform; 4 5 kinase C isoform; 4 5 kinase isoform 2 alpha; Diphosphoinositide kinase 2 alpha; Diphosphoinositide kinase 2-alpha; FLJ13267; Phosphatidylinositol 4 phosphate 5 kinase type 2 alpha; Phosphatidylinositol 4 phosphate 5 kinase type II alpha; Phosphatidylinositol-5-phosphate 4-kinase type II alpha; Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; PI(5)P 4-kinase type II alpha; PI42A_HUMAN; PI5P4KA; PIP4KII-alpha; PIP5K2; PIP5K2A; PIP5KII alpha; PIP5KII-alpha; PIP5KIIA; PIP5KIII; PIPK; PtdIns; PtdIns(4)P-5-kinase B isoform; PtdIns(4)P-5-kinase C isoform; PtdIns(5)P-4-kinase isoform 2-alpha; Type II phosphatidylinositol 4 phosphate 5 kinase 53 K isoform. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cell membrane By similarity. Nucleus. Cytoplasm. Note: May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light By similarity. Localization to the nucleus is modulated by the interaction with PIP4K2B. |
| 组织特异性 | Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. |
| 相似性 | Contains 1 PIPK domain. |
| 功能 | Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008] |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
PIP4K2A Antibody Blocking Peptide(bs-18536P)-500ug
￥880
