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| 规格： | 100ug | 产品价格： | ￥1880.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 规格： | 20ug | 产品价格： | ￥580.0 |
| 产品编号 | bs-0504P |
| 英文名称 | Recombinant human BMP-7 protein, His |
| 中文名称 | 重组人骨形态发生蛋白7蛋白 |
| 英文别名 | bone morphogenetic protein-7; BMP-7; rhBMP-7; osteogenic protein 1; BMP 7; Bone morphogenic protein 7; Eptotermin alfa; OP 1; OP-1; OP1; BMP7_HUMAN; Recombinant human BMP-7 protein, His |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 16 |
| 实际分子量 | 23-25 kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | 20mM Tris-HCl (pH8.0) with 150mM NaCl. |
| 研究领域 | Cancer > Cell cycle > Cell differentiation Cell Biology > Cell Cycle > Cell differentiation Developmental Biology > Organogenesis > Excretory system development > Kidney development Developmental Biology > Organogenesis > Nervous system development Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Bone Signal Transduction > Growth Factors/Hormones > TGF Stem Cells > Signaling Pathways > TGF beta > Secreted |
| 亚基 | Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Expressed in the kidney and bladder. Lower levels seen in the brain. |
| 翻译后修饰 | Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014). |
| 相似性 | Belongs to the TGF-beta family. |
| 功能 | Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq]. |
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文献和实验[IF={{ 0 }}] {Zhang et al. Bone morphogenetic protein 7 upregulates the expression of nestin and glial fibrillary acidic protein in rats with cerebral ischemia-reperfusion injury. (2013) Biomed.Re. 1:895-900} {Other} {}
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