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- Bioss
- bs-0245P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-0245P |
| 英文名称 | ELP1 Antibody Blocking Peptide |
| 中文名称 | 拟南芥IKI3封闭多肽 |
| 英文别名 | IKI3 family protein; Elongator complex protein 1; AtELP1; Elongator component 1; Protein ABA-OVERLY SENSITIVE 1; Protein ELONGATA 2; ELP1_ARATH. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 亚基 | Component of the RNA polymerase II elongator complex (Elongator) made of at least six subunits, ELP1/ELO2, ELP2, ELP3/ELO3, ELP4/ELO1, ELP5, and ELP6. |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Expressed in meristematic tissues of in roots, stems, leaves, seedlings, cotyledons, guard cells, floral buds, flowers, siliques, and shoot apices. |
| 相似性 | Belongs to the ELP1/IKA1 family. |
| 功能 | May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in the targeted degradation of IkB (1). IkB kinase alpha (IKK alpha), previously designated CHUK (2), interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, serines 32 and 36 (3). IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4). Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5). The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma (also designated NEMO), and each appears to make essential contributions to IkB phosphorylation (6). IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, interacting with NIK, IKK alpha and IKK beta and assembling them into an active kinase complex (7,8) |
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ELP1 Antibody Blocking Peptide(bs-0245P)-500ug
￥880
