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- bs-13709P
- 2025年10月16日
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500ug
| 产品编号 | bs-13709P |
| 英文名称 | LAP2 alpha Antibody Blocking Peptide |
| 中文名称 | 胸腺生成素LAP2封闭多肽 |
| 英文别名 | LAP2; LAP2A_HUMAN; Isoforms beta/gamma; Lamina associated polypeptide 2 alpha; Lamina associated polypeptide 2; Thymopoietin; Thymopoietin isoform alpha; TP alpha; TP; LAP2-alpha; LAP2 alpha. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages. |
| 亚细胞定位 | Nuclear |
| 组织特异性 | Expressed in many tissues. Most abundant in adult thymus and fetal liver. |
| 翻译后修饰 | Phosphorylated in a mitose-specific manner. |
| 相似性 | Belongs to the LEM family. Contains 1 LEM domain. Contains 1 LEM-like domain. |
| 功能 | Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A-type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eukaryotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, MANI, three isoforms of lamina-associated polypeptide 1 (LAP 1), and several isoforms of LAP 2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP 2 beta and the nucleoplasmic protein LAP 2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. LAP 2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent- and salt-resistant nucleoskeletal structure. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019] |
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LAP2 alpha Antibody Blocking Peptide(bs-13709P)-500ug
￥880
