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- bs-23497P
- 2025年10月16日
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500ug
| 产品编号 | bs-23497P |
| 英文名称 | CD1E Antibody Blocking Peptide |
| 中文名称 | T细胞表面糖蛋白CD1E封闭多肽 |
| 英文别名 | CD_antigen=CD1e; CD1e; CD1e antigen; CD1E antigen; CD1e molecule; CD1E_HUMAN; Differentiation antigen CD1-alpha-3; hCD1e; Leukocyte differentiation antigen; R2; R2G1; sCD1e; soluble; T-cell surface glycoprotein CD1e. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Cell Type Markers > CD > Non-lineage Immunology > Immunoglobulins > Receptors |
| 亚细胞定位 | Lysosome lumen and Golgi apparatus membrane. Early endosome. Late endosome. Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells. |
| 组织特异性 | Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues |
| 翻译后修饰 | Mono-ubiquitinated. Proteolytically cleaved in late endosomes to yield a soluble form. |
| 相似性 | Contains 1 Ig-like (immunoglobulin-like) domain. |
| 功能 | T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010] |
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CD1E Antibody Blocking Peptide(bs-23497P)-500ug
￥880
