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- Bioss
- bs-12388P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12388P |
| 英文名称 | KIF7 Antibody Blocking Peptide |
| 中文名称 | 驱动蛋白家族蛋白7封闭多肽 |
| 英文别名 | EQYK340; kif 7; Kif-7; KIF7_HUMAN; kinesin family member 7; kinesin like protein KIF7; Kinesin-like protein kif7; UNQ340. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Motor Proteins > Kinesin-like Stem Cells > Signaling Pathways > Hedgehog > Cytoplasmic |
| 亚基 | Interacts with GLI1, GLI2, GLI3, SMO and SUFU. Interacts with NPHP1. |
| 亚细胞定位 | Cell projection; cilium. SMO is required for its accumulation within cilia. Moves from the cilia base to the cilia tip in response to activation of the Shh pathway. |
| 组织特异性 | Embryonic stem cells, melanotic melanoma and Jurkat T-cells. |
| 相似性 | Belongs to the kinesin-like protein family. KIF27 subfamily. Contains 1 kinesin-motor domain. |
| 功能 | Acts as both a negative and positive regulator of sonic hedgehog (Shh) pathway, acting downstream of SMO. Negatively regulates the pathway by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates the pathway by preventing the processing of the transcription factor GLI3 into its repressor form. Required for efficient localization of GLI3 to cilia in response to Shh. May also act as a ciliary motor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | KIF7 is a 1,343 amino acid protein expressed in embryonic stem cells, melanotic melanoma and Jurkat T-cells. KIF7 is a member of the KIF27 subfamily of the kinesin-like protein family and contains one kinesin-motor domain. It is suggested that KIF7 may participate in the Hedgehog (Hh) signaling pathway by regulating the proteolysis and stability of GLI transcription factors. Hedgehog (Hh) signaling plays a critical role in embryonic development. |
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KIF7 Antibody Blocking Peptide(bs-12388P)-500ug
￥880
