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- Bioss
- bs-23457P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-23457P |
| 英文名称 | CAV3 Antibody Blocking Peptide |
| 中文名称 | 细胞质膜微囊蛋白-3封闭多肽 |
| 英文别名 | CAV 3; CAV3; Caveolin3; Caveolin 3; LGMD1C; M caveolin; VIP 21; VIP21; AI385751; Cav-3; caveolin-3; M-cav; M-caveolin; CAV3_MOUSE. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Cardiac metabolism Cardiovascular > Heart > Hypertrophy Developmental Biology > Organogenesis > Skeletal development > Muscle Signal Transduction > Metabolism > Plasma Membrane > Channels Signal Transduction > Metabolism > Vitamins / Minerals Signal Transduction > Protein Trafficking > Golgi Proteins |
| 亚基 | Homooligomer (By similarity). Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD (By similarity). Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling. |
| 亚细胞定位 | Golgi apparatus membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Membrane, caveola; Peripheral membrane protein (By similarity). Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). |
| 组织特异性 | Expressed predominantly in muscle. |
| 翻译后修饰 | Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2 (By similarity). |
| 相似性 | Belongs to the caveolin family. |
| 功能 | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types. |
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CAV3 Antibody Blocking Peptide(bs-23457P)-500ug
￥880
