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- Bioss
- bs-42015P
- 2025年10月16日
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- 规格：
100ug/500ug/20ug
| 规格： | 100ug | 产品价格： | ￥1880.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 规格： | 20ug | 产品价格： | ￥580.0 |
| 产品编号 | bs-42015P |
| 英文名称 | Recombinant human SLC12A3 protein, N-His Tag |
| 中文名称 | 重组钠氯离子转运蛋白 |
| 英文别名 | Na Cl symporter; Na-Cl symporter; NaCl electroneutral thiazide sensitive cotransporter; NCCT; S12A3_HUMAN; slc12a3; Solute carrier family 12 (sodium/chloride transporters) member 3; Solute carrier family 12 member 3; Thiazide sensitive Na Cl cotransporter; Thiazide sensitive sodium chloride cotransporter; Thiazide-sensitive sodium-chloride cotransporter; TSC; Recombinant human SLC12A3 protein, N-His Tag |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 20 |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | PBS (pH7.4) with 250mM NaCl. |
| 研究领域 | Cardiovascular > Blood > Blood Pressure regulation Metabolism > Types of disease > Cancer Signal Transduction > Metabolism > Plasma Membrane > Channels |
| 亚基 | Interacts with KLHL3. |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Predominant in kidney. |
| 翻译后修饰 | Ubiquitinated; ubiquitination is essential for regulation of endocytosis (By similarity). May be ubiquitinated by the BCR(KLHL3) complex. |
| 相似性 | Belongs to the SLC12A transporter family. |
| 功能 | Electrically silent transporter system. Mediates sodium and chloride reabsorption. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome. |
The purity of the protein is greater than 81% as determined by reducing SDS-PAGE.
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Recombinant human SLC12A3 protein, N-His Tag(bs-42015P)-100ug/500ug/20ug
￥580 - 5680
