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- bs-0661P
- 2025年10月16日
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500ug
| 产品编号 | bs-0661P |
| 英文名称 | MVP Antibody Blocking Peptide |
| 中文名称 | 肺耐药相关蛋白封闭多肽 |
| 英文别名 | 2310009M24Rik; LRP; Lung Resistance Related Protein; Lung resistance-related protein; Major Vault Protein; MVP; MVP_HUMAN; VAULT 1; VAULT1. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Drug resistance > Vault proteins Signal Transduction > Protein Trafficking > Nuclear Import / Export |
| 亚基 | The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540. |
| 亚细胞定位 | Cytoplasm. Nucleus, nuclear pore complex. |
| 组织特异性 | Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. |
| 翻译后修饰 | Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11. |
| 相似性 | Contains 9 MVP (vault) repeats. |
| 功能 | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
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MVP Antibody Blocking Peptide(bs-0661P)-500ug
￥880
