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- bs-16355P
- 2025年10月16日
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500ug
| 产品编号 | bs-16355P |
| 英文名称 | GTF2IRD2 Antibody Blocking Peptide |
| 中文名称 | 通用转录因子II重复结构域α2蛋白封闭多肽 |
| 英文别名 | FLJ21423; FLJ37938; FP630; general transcription factor II i repeat domain 2 alpha; general transcription factor II I repeat domain-containing protein 2A; GTF2I repeat domain containing 2; GTF2I repeat domain containing protein 2A; GTF2IRD2 alpha; GTF2IRD2A; GTD2A_HUMAN; MGC75203; Transcription factor GTF2IRD2 alpha; transcription factor GTF2IRD2. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Other factors |
| 亚细胞定位 | Nuclear |
| 组织特异性 | Ubiquitous. |
| 相似性 | Belongs to the TFII-I family. Contains 2 GTF2I-like repeats. |
| 功能 | GTF2IRD2 N-terminal half contains a leucine zipper motif, followed by 2 helix-loop-helix motifs (I repeats) that share homology with the TFII-I family of transcription factors. The C-terminal half of GTF2IRD2A contains a CHARLIE8 transposable element-like sequence, including 3 transposase-related domains that may be functional, and a BED zinc finger DNA-binding motif. It is inferred to be a transcription factor based on the presence of GTF2I-like repeats (containing helix-loop-helix motifs), also found in other proteins such as GTF2IRD1 and GTF2I. GTF2IRD2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. There are six different isoforms, generated by alternative splicing. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is one of several closely related genes on chromosome 7 encoding proteins containing helix-loop-helix motifs. These proteins may function as regulators of transcription. The encoded protein is unique in that its C-terminus is derived from CHARLIE8 transposable element sequence. This gene is located in a region of chromosome 7 that is deleted in Williams-Beuren syndrome, and loss of this locus may contribute to the cognitive phenotypes observed in this disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
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GTF2IRD2 Antibody Blocking Peptide(bs-16355P)-500ug
￥880
