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- Bioss
- bs-17157P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-17157P |
| 英文名称 | Tropomodulin 4 Antibody Blocking Peptide |
| 中文名称 | 原肌球蛋白调节蛋白4封闭多肽 |
| 英文别名 | Actin capping protein; SK TMOD; Sk-Tmod; Skeletal muscle tropomodulin; SKTMOD; TMOD 4; TMOD4; Tropomodulin 4 (muscle); Tropomodulin-4. |
| 纯化方法 | HPLC |
| 亚基 | Binds to the N-terminus of tropomyosin and to actin. |
| 亚细胞定位 | Cytoplasm, cytoskeleton. |
| 组织特异性 | Highly expressed in skeletal muscle. |
| 相似性 | Belongs to the tropomodulin family. |
| 功能 | Tropomodulin 4 prevents the elongation and depolymerization of the actin filaments at the pointed end, and intervenes in the formation of the short actin protofilament, which determines the structure of the membrane skeleton. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of actin filaments (1,2). A component of the membrane skeleton, TMOD binds to the amino terminus of tropomyosin, which coats the surface of actin, and thus blocks the elongation and depolymerization of actin filaments (3,4). Four TMOD isoforms, TMOD1 - TMOD4, have been characterized in humans (2). TMOD expression is isoform-specific; TMOD3 is expressed ubiquitously, whereas TMOD2 and TMOD4 are expressed in neuronal tissue and muscle, respectively (5). TMOD4, which has a similar organization to TMOD2, is intergenically spliced by the putative transformation suppressor gene product YL-1 (1). The human TMOD4 gene maps to the telomeric end of chromosome 1q12, and encodes a 351 amino acid protein (1,5). The expression and chromosomal location of the TMOD4 gene make it a candidate for limb girdle musclular dystrophy 1B (5). |
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Tropomodulin 4 Antibody Blocking Peptide(bs-17157P)-500ug
￥880
