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- Bioss
- bs-1197P
- 2025年10月16日
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500ug
| 产品编号 | bs-1197P |
| 英文名称 | TLR5 Antibody Blocking Peptide |
| 中文名称 | Toll样受体5封闭多肽 |
| 英文别名 | toll-like receptor 5; FLJ10052; MGC126430; MGC126431; TIL 3; TIL3; TLR 5; Toll like receptor 5; Toll like receptor 5 precursor; Toll/interleukin 1 receptor like protein 3;CD285; TLR5_MOUSE. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immunoglobulins > Receptors Immunology > Innate Immunity > Macrophage / Inflamm. Immunology > Innate Immunity > TLR Signaling |
| 亚基 | Homodimer both in the absence and presence of ligand. Binds MYD88 via their respective TIR domains (By similarity). |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein (By similarity). |
| 组织特异性 | Highly expressed in liver. Detected in lung and at very low levels in most other tissues. |
| 翻译后修饰 | Phosphorylated at Tyr-799 upon flagellin binding; required for signaling (By similarity). |
| 相似性 | Belongs to the Toll-like receptor family. Contains 16 LRR (leucine-rich) repeats. Contains 1 TIR domain. |
| 功能 | Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens. |
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TLR5 Antibody Blocking Peptide(bs-1197P)-500ug
￥880
