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- bs-3873P
- 2025年10月16日
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500ug
| 产品编号 | bs-3873P |
| 英文名称 | ATG4A Antibody Blocking Peptide |
| 中文名称 | 自噬相关蛋白4A封闭多肽 |
| 英文别名 | AI627006 ; APG4 autophagy 4 homolog A ; Apg4a ; ATG4 autophagy related 4 homolog A (S. cerevisiae) ; ATG4 autophagy related 4 homolog A ; ATG4A ; ATG4A_HUMAN ; Atg4al ; AUT like 2 cysteine endopeptidase ; AUT-like 2 cysteine endopeptidase ; Autl2 ; Autophagin 2 ; Autophagin-2 ; Autophagy related 4A cysteine peptidase ; Autophagy related cysteine endopeptidase 2 ; Autophagy related protein 4 homolog A ; Autophagy-related cysteine endopeptidase 2 ; Autophagy-related protein 4 homolog A ; AV169859 ; Cysteine protease ATG4A ; hAPG4A ; MGC107179 . |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Autophagy > APG gene products Cancer > Cell Death > Autophagy > Signal Transduction Cancer > Invasion/microenvironment > ECM > Extracellular matrix Cancer > Signal transduction > Autophagy Cardiovascular > Heart > Autophagy > APG gene products Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Other proteases Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > APG gene products |
| 亚细胞定位 | Cytoplasm (Probable). |
| 组织特异性 | Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. |
| 相似性 | Belongs to the peptidase C54 family. |
| 功能 | Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ATG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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