- ￥880
- Bioss
- bs-16056P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-16056P |
| 英文名称 | FCAMR Antibody Blocking Peptide |
| 中文名称 | CD351封闭多肽 |
| 英文别名 | CD351; Fc alpha/mu receptor; Fc receptor, IgA, IgM, high affinity; Fcamr; FCAMR_HUMAN; FKSG87; High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Immunity related factor; Receptor for Fc fragment of IgA and IgM. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immunoglobulins > Receptors |
| 亚细胞定位 | Cell membrane. |
| 组织特异性 | Expressed by mesangial cells. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc α/μ receptor (FCAMR) functions as a receptor for the Fc fragment of IgA and IgM and mediates their endocytosis. FCAMR is a 532 amino acid protein that is expressed in mesangial cells and is upregulated by IFNG/IFN-γ. It is also expressed in secondary lymphoid organs, such as lymph node and appendix, kidney and intestine, suggesting an important role of the receptor for immunity in these organs. |
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FCAMR Antibody Blocking Peptide(bs-16056P)-500ug
￥880
