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- bs-11653P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11653P |
| 英文名称 | BHLHB9 Antibody Blocking Peptide |
| 中文名称 | p60TRP蛋白封闭多肽 |
| 英文别名 | Basic helix loop helix domain containing class B 9; BHLHB 9; bHLHB9; KIAA1701; p60 like protein; p60TRP; Protein BHLHb9; Transcription regulator of 60 kDa; BHLH9_HUMAN . |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Mainly cytoplasmic, and nuclear at lower level. |
| 组织特异性 | Highly expressed in brain. Not expressed in lung or liver. Down-regulated in brain from patients suffering from Alzheimer disease. |
| 相似性 | Belongs to the GPRASP family. |
| 功能 | BHLHB9, or basic helix loop helix domain containing, class B 9, interacts with the Ran-binding-protein-5 (RanBP5) and the protein-phosphatase-2A (PP2A). It can also affect NNT1 and p48ZnF signaling and is down-regulated in the brain of AD subjects. Thus BHLHB9 may have a possible pivotal role in the control of cellular aging and survival. Hypermethylation of the BHLHB9 gene occurs in premalignant lesions and accumulates during tumorigenesis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Basic helix-loop-helix (bHLH) proteins are a group of transcription factors that influence the regulation of neurogenesis, cardiogenesis, myogenesis, differentiation and cell proliferation. p60TRP (p60-transcription-regulator-protein), also known as BHLHb9 (basic helix-loop-helix domain containing, class B, 9) or p60-like protein, is a 547 amino acid cytoplasmic and nuclear protein that belongs to the GPRASP family. A few members of the GRASP family are considered G protein-coupled receptors that play a role in many different stimulus-response pathways. Highly expressed in brain, p60TRP may be involved in the control of cellular aging and survival. In colon cancer cells, p60TRP is down regulated due to CpG hypermethylation of its promoter, and patients suffering from Alzheimer disease have low levels of p60TRP. p60TRP binds to karyopherin ∫3, also known as Ran BP-5, and protein-phosphatase-2A (PP2A), and is encoded by a gene located on human chromosome Xq22.1. |
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BHLHB9 Antibody Blocking Peptide(bs-11653P)-500ug
￥880
