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- bs-2651P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-2651P |
| 英文名称 | ELAVL1 Antibody Blocking Peptide |
| 中文名称 | ELAVL1封闭多肽 |
| 英文别名 | HuR / ELAVL1; ELAV (embryonic lethal abnormal vision Drosophila) like 1; ELAV like 1; ELAV-like protein 1; ELAV1; ELAV1_HUMAN; Embryonic lethal abnormal vision drosophila homolog like 1; Hu Antigen R; Hu-antigen R; Hua; HuR; MelG. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > RNAi Epigenetics and Nuclear Signaling > RNAi > Argonaute and Piwi |
| 亚基 | Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with ANP32A, EIF2C1 and EIF2C2. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2. |
| 组织特异性 | Ubiquitous. |
| 翻译后修饰 | Phosphorylated by MAPKAPK2.
Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge. |
| 相似性 | Belongs to the RRM elav family.
Contains 3 RRM (RNA recognition motif) domains. |
| 功能 | Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression. [provided by RefSeq]. |
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ELAVL1 Antibody Blocking Peptide(bs-2651P)-500ug
￥880
