PAPSS1 Antibody Blocking Peptide(bs-9029P)-500ug

PAPSS1 Antibody Blocking Pepti

de(bs-9029P)-500ug
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  • bs-9029P
  • 2025年10月16日
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      500ug

    产品编号bs-9029P
    英文名称PAPSS1 Antibody Blocking Peptide
    中文名称腺苷酸硫酸激酶1封闭多肽
    英文别名Adenylyl-sulfate kinase; Adenylylsulfate 3''-phosphotransferase; APS kinase; ATP-sulfurylase; ATPSK 1; ATPSK1; Bifunctional 3' phosphoadenosine 5' phosphosulfate synthetase 1; PAPS synthase 1; PAPS synthetase 1; PAPS1_HUMAN; PAPSS 1; PAPSS; PAPSS1; SAT; SK 1; SK1; Sulfate adenylate transferase; Sulfurylase kinase 1; 3 prime phosphoadenosine 5 prime phosphosulfate synthase 1; 3' phosphoadenosine 5' phosphosulfate synthase 1; 3''-phosphoadenosine-5''-phosphosulfate synthase; Adenosine-5''-phosphosulfate 3''-phosphotransferase.
    纯化方法HPLC
    研究领域

    Cell Biology > Other Antibodies > Other Antibodies

    组织特异性Expressed in cartilage and adrenal gland.
    相似性In the N-terminal section; belongs to the APS kinase family.
    In the C-terminal section; belongs to the sulfate adenylyltransferase family.
    功能Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料PAPSS2 is one of the two PAPS synthetases. Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes. SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2.Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetases (PAPS synthetase or PAPSS), also designated sulfurylase kinase (SK), are important for sulfate assimilation in the sulfur metabolism pathway. PAPPS proteins are bifunctional enzymes with APS kinase and ATP sulfurylase activity, which mediate two steps in the sulfate activation pathway. The PAPSS proteins belong to the APS kinase family and to the sulfate adenylyltransferase family of proteins. In mammals, PAPSS proteins are the sole source of sulfate. During postnatal growth, PAPSS proteins may play a role in skeletogenesis. Defects in the PAPSS2 gene can cause the Pakistani type of spondyloepimetaphyseal dysplasia (SEMD), an autosomal recessive form of SEMD characterized by short, bowed limbs, enlarged knee joints and mild brachydactyly.

     

     

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