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- bs-11816P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11816P |
| 英文名称 | CBLN4 Antibody Blocking Peptide |
| 中文名称 | 小脑肽4封闭多肽 |
| 英文别名 | CBLN 4; CBLNL1; Cerebellin 4; Cerebellin 4 precursor; Cerebellin like glycoprotein 1; Cerebellin precursor like 1; Cerebellin4; CBLN4_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers. May interact with CBLN1, CBLN2 and CBLN3 |
| 亚细胞定位 | Secreted. Cell junction, synapse |
| 相似性 | Contains 1 C1q domain. |
| 功能 | Cerebellin is a sixteen amino acid peptide found mainly in the adrenal medulla, where it has been shown to have a neuromodulatory function. Cerebellin is derived from precerebellin, a protein with sequence similarity to the noncollagen domain of complement component C1qB. CBLN4 is a glycoprotein which shares sequence similarity with precerebellin. CBLN4 may be involved in synaptic functions in the CNS. It can enable ER export and secretion of CBLN3. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3) and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. Cerebellin and its metabolite, des-Ser(1)Cer, are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other’s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of Cerebellin have been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for Cerebellin in the pathology of these diseases. |
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CBLN4 Antibody Blocking Peptide(bs-11816P)-500ug
￥880
