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- bs-15486P
- 2025年10月16日
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500ug
| 产品编号 | bs-15486P |
| 英文名称 | HIC2 Antibody Blocking Peptide |
| 中文名称 | 肿瘤异常甲基化蛋白2封闭多肽 |
| 英文别名 | HIC1 related gene on chromosome 22; HIC2; Hic3; HRG22; Hypermethylated in cancer 2 protein; KIAA1020; ZBTB30; Zinc finger and BTB domain-containing protein 30; ZNF907; HIC2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Krueppel like factor Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger Epigenetics and Nuclear Signaling > Transcription > Krueppel like factor Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚基 | Self-associates. Interacts with HIC1. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Highest levels in cerebellum. |
| 相似性 | Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily. Contains 1 BTB (POZ) domain. Contains 5 C2H2-type zinc fingers. |
| 功能 | Transcriptional repressor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities. |
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HIC2 Antibody Blocking Peptide(bs-15486P)-500ug
￥880
