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- bs-13997P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-13997P |
| 英文名称 | CORO2B Antibody Blocking Peptide |
| 中文名称 | 肌动蛋白结合蛋白2B封闭多肽 |
| 英文别名 | Actin binding protein; Clipin-C; CLIPINC; COR2B_HUMAN; CORO2B; Coronin actin binding protein 2B; Coronin; Coronin-2B; Coronin-like protein C; Protein FC96. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Assembly Tags & Cell Markers > Cell Type Markers > Neuroscience Markers > Growth Cone marker Tags & Cell Markers > Subcellular Markers > Cytoskeleton > Actin |
| 亚基 | Binds to F-actin and to vinculin. |
| 亚细胞定位 | Cytoplasm; cytoskeleton. |
| 组织特异性 | Expressed predominantly in brain. |
| 相似性 | Belongs to the WD repeat coronin family. Contains 5 WD repeats. |
| 功能 | May play a role in the reorganization of neuronal actin structure. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Coronins are a family of WD repeat-containing, actin-binding proteins that localize to submembraneous areas and regulate cell motility and cytoskeletal rearrangement. Coronin 1A (CORO1A, CLIPINA, CLABP, TACO, p57) can form coiled coil-mediated homotrimeric complexes that influence early phagosome formation. PKC-dependent phosphorylation of Coronin 1B (CORO1B) at Serine 2 regulates leading edge dynamics and cell motility in fibroblasts through interactions with Arp2/3 complex. Coronin 1C (CORO1C, Coronin 3, HCRNN4) is abundant in differentiating Neuro-2a cells, PC-12 cells and primary oligodendrocytes, where it is thought to influence neuron morphogenesis and migration. Coronin 2A (CORO2A, CLIPINB, IR10, WDR2) is a component of the approximately 1.5-2 megadalton N-CoR (nuclear receptor corepressor) complex of 10-12 proteins, which recruits HDACs to generate repressive chromatin. Coronin 7 (CORO7, CRN7) localizes to the Golgi membrane and influences the organization of intracellular membrane compartments and vesicular trafficking. Coronin 2B (CORO2B, CLIPINC) and Coronin 6 (CORO6) are similar to other members of this family, since they possess a conserved basic N-terminal motif and 3-10 WD repeats clustered in one to two core domains. |
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CORO2B Antibody Blocking Peptide(bs-13997P)-500ug
￥880
