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- bs-2622P
- 2026年10月10日
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500ug
| 产品编号 | bs-2622P |
| 英文名称 | IL21R Antibody Blocking Peptide |
| 中文名称 | 白介素21受体封闭多肽 |
| 英文别名 | IL 21R; IL-21R; IL21 Receptor; IL21R; Interleukin 21 receptor; MGC10967; NILR; IL21R_HUMAN; CD360; IL-21 receptor; IL21 Receptor; Interleukin-21 receptor; Novel interleukin receptor. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Cytokines > Interleukins |
| 亚基 | Heterodimer with the common gamma subunit. Associates with JAK1. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen. |
| 翻译后修饰 | C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame. |
| 相似性 | Belongs to the type I cytokine receptor family. Type 4 subfamily._x000D_
Contains 2 fibronectin type-III domains. |
| 功能 | This is a receptor for interleukin-21. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] |
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文献和实验相关实验
Dual-Color ELISPOT Assay for the Simultaneous Detection of IL-2 and/or IFN- Secreting T Cells
, activate AEC buffer using H2 O2 (see Step 25). Anti-CD3 monoclonal antibody (mAb) (Fisher Scientific) Blocking buffer for ELISPOT assay CEF peptide pool (available from the NIH AIDS Research and Reagent Program and other commercial
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IL21R | CD360 Ab Blocking Peptide(bs-2622P)-500ug
￥880
