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- Bioss
- bs-11772P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11772P |
| 英文名称 | Tetanus Toxin heavy chain Antibody Blocking Peptide |
| 中文名称 | 破伤风毒素重链封闭多肽 |
| 英文别名 | Tentoxylysin; Tetanus toxin chain H; Tetanus toxin heavy chain; TETX_CLOTE. |
| 纯化方法 | HPLC |
| 亚基 | he precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle. |
| 相似性 | Belongs to the peptidase M27 family. |
| 功能 | Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008] |
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Tetanus Toxin heavy chain Antibody Blocking Peptide(bs-11772P)-500ug
￥880
