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- Bioss
- bs-17509P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-17509P |
| 英文名称 | SKOR2 Antibody Blocking Peptide |
| 中文名称 | SKOR2蛋白封闭多肽 |
| 英文别名 | CORL2; Functional smad suppressing element 18; Functional Smad-suppressing element on chromosome 18; Fussel-18; FUSSEL18; Ladybird homeobox corepressor 1-like protein; LBX1 corepressor 1-like protein; SKI family transcriptional corepressor 2; SKOR2; SKOR2_HUMAN. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Nucleus. Cytoplasm. |
| 组织特异性 | Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level). |
| 相似性 | Belongs to the SKI family. |
| 功能 | Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The sloan kettering virus (Ski) family of nuclear oncoproteins act as transcriptional regulators of TGF-β by interacting directly with SMAD proteins. Fussel-18 (functional Smad-suppressing element on chromosome 18), also known as SKOR2 (Ski family transcriptional corepressor 2), LBX1 corepressor 1-like protein, ladybird homeobox corepressor 1-like protein or CORL2, is a 1,001 amino acid protein that belongs to the Ski family. Localizing to nucleus as well as cytoplasm, Fussel-18 is expressed in cerebellum, spinal cord and testis. Fussel-18 acts as an antagonist to TGF-β in the nervous system, possibly by functioning as a transcriptional repressor of SMAD2 and SMAD3. Existing as two alternatively spliced isoforms, the gene encoding Fussel-18 maps to human chromosome 18q21.1 and mouse chromosome 18 E3. |
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SKOR2 Antibody Blocking Peptide(bs-17509P)-500ug
￥880
