- ￥880
- Bioss
- bs-2564P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-2564P |
| 英文名称 | CLEC4A Antibody Blocking Peptide |
| 中文名称 | C型凝集素结构域家族4成员A封闭多肽 |
| 英文别名 | C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6; C type lectin; C type lectin DDB27; C type lectin superfamily 6; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6; C-type lectin superfamily member 6; C-type lectin DDB27; C-type lectin domain family 4 member A; C-type lectin domain family 4, member A; C-type lectin domain family 4, member a2; C-type lectin superfamily member 6; CLC4A_HUMAN; Clec4a; Clec4a2; CLECSF6; DCIR; Dcir1; DDB27; Dendritic cell immunoreceptor; HDCGC13P; Lectin like immunoreceptor; Lectin, C-type, superfamily member 6; Lectin-like immunoreceptor; LLIR. |
| 纯化方法 | HPLC |
| 亚基 | May interact with PTPN6 via its ITIM motif. |
| 亚细胞定位 | Membrane; Single-pass type II membrane protein. |
| 组织特异性 | Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). |
| 相似性 | Contains 1 C-type lectin domain. |
| 功能 | May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
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CLEC4A Antibody Blocking Peptide(bs-2564P)-500ug
￥880
