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- Bioss
- bs-2999P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-2999P |
| 英文名称 | Bmi1 Antibody Blocking Peptide |
| 中文名称 | 组蛋白相关Bmi1封闭多肽 |
| 英文别名 | B lymphoma Mo MLV insertion region; Bmi 1; BMI-1; MGC12685; Murine leukemia viral (bmi 1) oncogene homolog; Oncogene BMI 1; PCGF 4; PCGF4; Polycomb complex protein BMI 1; Polycomb complex protein BMI-1; Polycomb group ring finger 4; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; RNF51; RAD18; BMI1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell cycle > Cell differentiation Cancer > Oncoproteins/suppressors > Oncoproteins Cell Biology > Cell Cycle > Cell differentiation Epigenetics and Nuclear Signaling > Chromatin Remodeling > Polycomb Silencing > PRC2 Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes Stem Cells > Hematopoietic Progenitors > Intracellular Molecules |
| 亚细胞定位 | Nucleus. Cytoplasm. |
| 翻译后修饰 | Monoubiquitinated. May be polyubiquitinated; which does not lead to proteasomal degradation. |
| 相似性 | Contains 1 RING-type zinc finger. |
| 功能 | Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway.Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility. |
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Bmi1 Antibody Blocking Peptide(bs-2999P)-500ug
￥880
