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500ug
| 产品编号 | bs-10718P |
| 英文名称 | MMP24 Antibody Blocking Peptide |
| 中文名称 | 基质金属蛋白酶-24封闭多肽 |
| 英文别名 | Matrix metallopeptidase 24 (membrane inserted); Matrix metallopeptidase 24; Membrane type 5 matrix metalloproteinase; Membrane type matrix metalloproteinase 5; Membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase; MMP 24; MMP 25; MMP-24; Mmp24; MMP24_HUMAN; MMP25; MT MMP5; MT-MMP 5; MT5 MMP; MT5-MMP; MT5MMP; MTMMP5; Processed matrix metalloproteinase-24. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Extracellular matrix > MMPs Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Metalloprotease > MMPs Neuroscience > Cell Adhesion Proteins > ECM Proteins Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > MMP |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein; Extracellular side.
Processed matrix metalloproteinase-24: Secreted, extracellular space, extracellular matrix. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. |
| 组织特异性 | Expressed in brain. Expressed at low level in testis. |
| 翻译后修饰 | The precursor is cleaved by a furin endopeptidase. |
| 相似性 | Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains. |
| 功能 | Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008] |
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MMP24 Antibody Blocking Peptide(bs-10718P)-500ug
¥880







