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- bs-11698P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11698P |
| 英文名称 | FICD Antibody Blocking Peptide |
| 中文名称 | 舞蹈症蛋白相互作用蛋白13封闭多肽 |
| 英文别名 | HIP13; Adenosine monophosphate-protein transferase FICD; AMPylator FICD; FIC domain containing; FIC domain containing protein; FIC domain-containing protein; Fic S phase protein cell division homolog; ficd; FICD_HUMAN; HIP-13; HIP13; Huntingtin interacting protein 13; Huntingtin interacting protein E; Huntingtin interactor protein E; Huntingtin yeast partner E; Huntingtin-interacting protein 13; Huntingtin-interacting protein E. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease > Huntington's disease |
| 亚基 | Interacts with HD. |
| 亚细胞定位 | Membrane; Single-pass membrane protein (Potential). |
| 组织特异性 | Ubiquitous. |
| 相似性 | Belongs to the fic family. Contains 1 fido domain. Contains 2 TPR repeats. |
| 功能 | Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Huntingtin yeast partner E is a 458 amino acid single-pass membrane protein. HYPE is thought to interact with Huntingtin, a protein which induces neurodegeneration when mutated. HYPE also contains two tetratricopeptide repeats (TPR), which may be involved in protein-protein interaction. The gene that encodes HYPE is located on chromosome 12, which encodes over 1,100 genes within 132 million bases and makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. |
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FICD Antibody Blocking Peptide(bs-11698P)-500ug
￥880
