- ￥880
- Bioss
- bs-11679P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11679P |
| 英文名称 | CTNND2 Antibody Blocking Peptide |
| 中文名称 | δ-连环蛋白封闭多肽 |
| 英文别名 | Catenin (cadherin associated protein) delta 2; Catenin delta 2; Catenin delta-2; CTND2_HUMAN; CTNND 2; CTNND2; Delta catenin; Delta-catenin; GT 24; GT24; Neural plakophilin related arm repeat protein; Neural plakophilin related armadillo repeat protein; Neural plakophilin-related ARM-repeat protein; Neurojungin; NPRAP |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Other factors Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Catenins Stem Cells > Neural Stem Cells > Intracellular |
| 亚基 | Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with ARHGEF28. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Predominantly expressed in brain. |
| 翻译后修饰 | O-glycosylated. Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the beta-catenin family. Contains 9 ARM repeats. |
| 功能 | Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Alpha-, Beta-, Gamma-, and Delta -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Alpha-catenin interacts with E-cadherin associated protein and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. Beta-catenin also complexes with the tumor suppressor protein APC. Gamma-catenin, also known as plakoglobin, is a protein that binds ?catenin and N-cadherin. Gamma-catenin interacts with presenilin 1 and is expressed in the brain. The gene encoding Gamma-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding Gamma-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. In addition, the transmembrane phosphatase PTPm associates with catenin/ cadherin complexes and may regulate complex signaling. |
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CTNND2 Antibody Blocking Peptide(bs-11679P)-500ug
￥880
