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- Bioss
- bs-11573P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11573P |
| 英文名称 | DPF1 Antibody Blocking Peptide |
| 中文名称 | 神经特异性转录因子DPF1封闭多肽 |
| 英文别名 | NeuroD4; BAF45B; BRG1-associated factor 45B; D4; DPF1; DPF 1; DPF=1; DPF1_HUMAN; NEUD4; NEUD 4; Zinc and double PHD fingers family 1; Zinc finger protein neuro-d4. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH Neuroscience > Neurology process > Neural Signal Transduction |
| 亚基 | Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 相似性 | Belongs to the requiem/DPF family. Contains 2 PHD-type zinc fingers. |
| 功能 | May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DPF1 is a 353 amino acid protein that contains two PHD-type zinc fingers and belongs to the requiem/DPF family. Localized to both the nucleus and the cytoplasm, DPF1 is thought to play an important role in the regulation of neuronal cell survival. Specifically, DPF1 may function as a neurospecific transcription factor that binds DNA and participates in cell cycle progression. Human and rat DPF1 share 93% sequence identity, suggesting a conserved role between species. Multiple isoforms of DPF1 exist due to alternative splicing events. |
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DPF1 Antibody Blocking Peptide(bs-11573P)-500ug
￥880
