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- Bioss
- bs-11661P
- 2025年10月16日
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500ug
| 产品编号 | bs-11661P |
| 英文名称 | KCNE3 Antibody Blocking Peptide |
| 中文名称 | 钾离子通道蛋白家族成员3封闭多肽 |
| 英文别名 | Cardiac voltage gated potassium channel accessory subunit; HOKPP; KCNE 3; Minimum potassium ion channel related peptide 2; minK related peptide 2; MiRP 2; MiRP2; Potassium voltage gated channel subfamily E member 3; Potassium voltage gated channel, Isk related family, member 3; Voltage gated K+ channel subunit MIRP2; KCNE3_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Associates with KCNC4/Kv3.4. May associate with KCNQ1/KCLQT1. |
| 亚细胞定位 | Cell Membrane |
| 组织特异性 | Widely expressed with highest levels in kidney and moderate levels in small intestine. |
| 相似性 | Belongs to the potassium channel KCNE family. |
| 功能 | KCNE3 (also known as MiRP2) is an ancillary protein that functions as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. It modulates the gating kinetics of the complex, as well as enhancing channel stability. The complex of KCNE3 with KCNQ1/KCLQT1 is postulated form the intestinal cAMP-stimulated potassium channel that is involved in chloride secretion. KCNE3 in complex with KCNC4/Kv3.4 is thought to form the subthreshold voltage-gated potassium channel that establishes the resting membrane potential in skeletal muscle. Altered activity of the KCNE3/Kv3.4 channel induced by the Abeta peptide is thought to result in the upregulation of the transient outward potassium current, a significant step in the etiology of Alzheimer's disease. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]. |
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KCNE3 Antibody Blocking Peptide(bs-11661P)-500ug
￥880
