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- bs-11659P
- 2025年10月16日
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500ug
| 产品编号 | bs-11659P |
| 英文名称 | GRC5/PHF2 Antibody Blocking Peptide |
| 中文名称 | GRC5蛋白封闭多肽 |
| 英文别名 | CENP-35; GRC5; PHF2; JHDM1E; Jumonji C domain containing histone demethylase 1E; jumonji containing protein; Lysine-specific demethylase PHF2; PHD finger protein 2; Phf2; PHF2_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Component of the PHF2-ARID5B complex, at least composedof PHF2 and ARID5B. Interacts with HNF4A and NR1H4. |
| 亚细胞定位 | Nucleus, nucleolus. |
| 组织特异性 | Widely expressed, including in liver (at protein level). |
| 翻译后修饰 | Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex. |
| 相似性 | Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. Contains 1 JmjC domain. Contains 1 PHD-type zinc finger. |
| 功能 | Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008] |
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GRC5/PHF2 Antibody Blocking Peptide(bs-11659P)-500ug
￥880
