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- Bioss
- bs-1188P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-1188P |
| 英文名称 | FOSL2 Antibody Blocking Peptide |
| 中文名称 | fos相关抗原2封闭多肽 |
| 英文别名 | FLJ23306; Fos L2; FOS like antigen 2; Fos related antigen 2; FosL 2; FOSL2; FOSL2_HUMAN; FRA 2; fos-related antigen 2. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Leucine Zipper |
| 亚基 | Heterodimer |
| 亚细胞定位 | Nuclear |
| 相似性 | Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain. |
| 功能 | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Fos and Jun dimerize to form Activator Protein 1 (AP1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13 acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP1 dependent genes. |
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FOSL2 Antibody Blocking Peptide(bs-1188P)-500ug
￥880
