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- Bioss
- bs-15374P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-15374P |
| 英文名称 | GPCR TGR7 Antibody Blocking Peptide |
| 中文名称 | G蛋白偶联受体TGR7蛋白封闭多肽 |
| 英文别名 | Beta-alanine receptor; G-protein coupled receptor TGR7; Mas-related G-protein coupled receptor member D; MRGD; MRGPRD; MRGRD; TGR7; MRGRD_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > GPCR > More GPCR Neuroscience > Sensory System > Somatosensory system > Nociception Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. Mas subfamily. |
| 功能 | May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Mas-related G protein-coupled receptors are sensory neuron-specific G protein-coupled receptors that are usually involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGD (MAS-related GPR, member D), also known as MRGPRD or TGR7, is a 321 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family and the Mas subfamily. MRGD is suggested to function specifically as a receptor for beta-alanine, a naturally occurring beta amino acid. Beta-alanine induces Ca2+ influx and decreases forskolin-stimulated cAMP production in cells expressing MRGD. Neurons of outer epidermis that express MRGD act as nociceptors in which they respond indirectly to external stimuli by detecting ATP release in the skin. MRGD is encoded by a gene located on human chromosome 11q13.2. |
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GPCR TGR7 Antibody Blocking Peptide(bs-15374P)-500ug
￥880
