- ￥880
- Bioss
- bs-2455P
- 2025年10月16日
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500ug
| 产品编号 | bs-2455P |
| 英文名称 | CLEC7A Antibody Blocking Peptide |
| 中文名称 | β葡聚糖受体封闭多肽 |
| 英文别名 | Dectin1; Dectin-1; Dectin 1; CLECSF12; C-type lectin domain family 7 member A; beta Glucan Receptor; Beta GR; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; Clec7a; CANDF4; DECTIN1; CLEC7A protein; Clecsf12; Dectin 1; DECTIN 1 receptor; Dectin1; Dendritic cell associated C type lectin 1; Lectin like receptor 1; beta Glucan Receptor; Putative transmembrane protein dectin 1; CLC7A_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Macrophage / Inflamm. |
| 亚基 | Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens. |
| 亚细胞定位 | Cell membrane; Single-pass type II membrane protein. |
| 组织特异性 | Detected in dendritic cells, in paracortical and medullary regions of lymph nodes, and in spleen red pulp and white pulp. |
| 翻译后修饰 | on tyrosine residues in response to glucan binding. |
| 相似性 | Contains 1 C-type lectin domain. |
| 功能 | Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq]. |
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CLEC7A Antibody Blocking Peptide(bs-2455P)-500ug
￥880
