- ￥880
- Bioss
- bs-11463P
- 2025年10月16日
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500ug
| 产品编号 | bs-11463P |
| 英文名称 | PPFIA1 Antibody Blocking Peptide |
| 中文名称 | 酪氨酸磷酸酶受体相互作用蛋白Liprin α1封闭多肽 |
| 英文别名 | PPFIA1; LAR interacting protein 1; LIP 1; LIP.1; LIP1; LIPRIN; MGC26800; PPFIA 1; PPFIA1; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 1; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1; PTPRF interacting protein alpha 1; LIPA1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins Signal Transduction > Protein Phosphorylation > Tyrosine Phosphatases |
| 亚基 | Forms homodimers and heterodimers with liprins-alpha andliprins-beta. Interacts with the second PTPase domain of PTPRD,PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1 |
| 亚细胞定位 | Cytoplasm. Note=Colocalizes with PTPRF atthe ends of focal adhesions most proximal to the cell nucleus. |
| 组织特异性 | Ubiquitous. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the liprin family. Liprin-alpha subfamily. Contains 3 SAM (sterile alpha motif) domains. |
| 功能 | This protein is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the LARprotein-tyrosine phosphatase-interacting protein (liprin) family.Liprins interact with members of LAR family of transmembraneprotein tyrosine phosphatases, which are known to be important foraxon guidance and mammary gland development. This protein binds tothe intracellular membrane-distal phosphatase domain of tyrosinephosphatase LAR, and appears to localize LAR to cell focaladhesions. This interaction may regulate the disassembly of focaladhesion and thus help orchestrate cell-matrix interactions.Alternatively spliced transcript variants encoding distinctisoforms have been described. [provided by RefSeq, Jul 2008]. |
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PPFIA1 Antibody Blocking Peptide(bs-11463P)-500ug
￥880
