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- Bioss
- bs-16361P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-16361P |
| 英文名称 | GTF3C5 Antibody Blocking Peptide |
| 中文名称 | 通用转录因子3C多肽5/TFIIIC90封闭多肽 |
| 英文别名 | FLJ20857; General transcription factor 3C polypeptide 5; General transcription factor IIIC polypeptide 5 63kDa; GTF3C5; TF3C epsilon; TF3C-epsilon; TF3C5_HUMAN; TFIIIC 63 kDa subunit; TFiiiC2 63; TFIIIC63; TFIIICepsilon; Transcription factor IIIC 63 kDa subunit; Transcription factor IIIC epsilon subunit; Transcription factor IIIC subunit epsilon. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Other factors Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol III Transcription Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the TFIIIC subunit 5 family. |
| 功能 | Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB’’, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB. |
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GTF3C5 Antibody Blocking Peptide(bs-16361P)-500ug
￥880
